BY2KS2 - Biomedical Sciences

The effect of three different monoclonal antibodies on non Hodgkin's lymphoma

Proposal summary

Monoclonal antibodies are made in the laboratory and their prime function is to enhance the bodies own immune system and eradicate any disease that may be present in the body more effectively than the bodies own immune system alone.

At present There have been three monoclonal antibodies that have been identified to treat non Hodgkin's lymphoma. All three have a different mode of action, have their benefits and limitations. I will therefore be looking at all these factors and more to come to an overall conclusion to determining the

The point to my research will be to compare and contrast the effects of these different monoclonal antibodies on the cancer and to determine their effectiveness at improving their state of and eradicating the cancer altogether.

I will be monitoring from different accounts, journals, books and more, looking at various trials that have been carried out to determine the relative effectiveness of each monoclonal antibody to come to a conclusion as to which is the most useful and the least harmful to the population.

I will be carrying out a systemic review which doesent just focus on the positives and research that supports my theories I will also be taking into account the negatives that accompany each monoclonal antibody to form an in depth review on their performance in the body and their safety in the population.

Objectives of proposed work:

Monoclonal antibodies are made in the laboratory and their prime function is to enhance the bodies own immune system and eradicate any disease that may be present in the body more effectively than the bodies own immune system alone.

At present There have been three monoclonal antibodies that have been identified to treat non Hodgkin's lymphoma. All three have a different mode of action, have their benefits and limitations. I will therefore be looking at all these factors and more to come to an overall conclusion to determining the

The point to my research will be to compare and contrast the effects of these different monoclonal antibodies on the cancer and to determine their effectiveness at improving their state of and eradicating the cancer altogether.

I will be monitoring from different accounts, journals, books and more, looking at various trials that have been carried out to determine the relative effectiveness of each monoclonal antibody to come to a conclusion as to which is the most useful and the least harmful to the population.

I will be carrying out a systemic review which doesn't just focus on the positives and research that supports my theories I will also be taking into account the negatives that accompany each monoclonal antibody to form an in depth review on their performance in the body and their safety in the population.

I will determine and assess other research done thus far and state the strengths and weaknesses of the research to make the population more aware. I will critically review the findings to assess the validity of findings from that particular author.

I will also review how many people have the cancer and who is being treated and who in the population would benefit from this treatment via monoclonal antibodies.

Strategic relevance of proposed work (not exceeding 750 characters):

Non Hodgkin's lymphoma is a well known cancer and three monoclonal antibodies have been developed to help the population fight against it.

Therefore it would be in the populations interest to find out which monoclonal antibody is the most effective and least harmful to the body.

Also I hope to increase the population's knowledge on non Hodgkin's lymphoma, the successes rates to eradicating the cancer and the unfortunate cases in which the cancer has succeeded. This is so that they understand the importance of the cancer, how common it is and the need to beat the cancer with the use of monoclonal antibodies.

Also the future of monoclonal antibodies and how they will improve with time and effort.

Also a company called NICE, analyze medical treatment and technologies I order to advise healthcare providers on what to prescribe the population. So as a consequence of research that I conduct there will be more information available to NICE to determine the cost to benefit ratio of each of the medical treatments.

I will also be finding out approximately how many people in the population have this type of cancer and the type of people being treated, for example their medical condition, lifestyle and more, and who exactly would benefit from this research.

6 Details of proposed investigation (Maximum of 5 sides of A4, Arial font 11):

I am carrying out a systemic review on the effect of three different monoclonal antibodies on a type of cancer called non hodgkins lymphoma. I will be looking at various resources that will support and contradict my research and look at trials carried out in the population to see the effectiveness of the relative monoclonal antibodies in real life-.

I am going to compare and contrast the three monoclonal antibodies in relation to their mechanism of action, their invasiveness in the human body, the side effects that the individual may incur if the monoclonal antibody is used, the benefits to the individual. This is all to come to a conclusion of which is the best monoclonal antibody to treat non Hodgkin's lymphoma.

The main points will be to consider the following:

1. the mechanism of actions of the named monoclonal antibody

2. the structure of the monoclonal antibody and how it relates to its function

3. comparing and contrasting all three monoclonal antibodies to see which one will be the most effective in eradicating the cancer

4. looking at a variety of sources including journals and clinical trials to see the most effective in the lab and in the general population

5. the cancer it self; how harmful it is to the population, success rates at eradicating the cancer, how it spreads in the body and how it can be stopped

The reason I chose to research this cancer is that it is quite a common cancer as it is a cancer of the white blood cells and these are the cells in which the body uses to respond to an infection and if the cells are not working then an alternative method to fight the cancer must be used and these monoclonal antibodies may be the answer.

Also there are more than 30 different sorts of non-Hodgkin's lymphoma, and everyone's experience is different. There are treatments for all the forms of non-Hodgkin's lymphoma, and many patients respond to treatment. I will be looking at the different types of non Hodgkin's lymphoma and which monoclonal antibodies are the ,most effective and the ones the population most respond to.

Monoclonal antibodies are a relatively new class of drug, and its development is one of the biggest advances in the treatment of non-Hodgkin's lymphoma in recent years. The aim of monoclonal antibody treatment is to destroy the non-Hodgkin's lymphoma cells in a targeted way and to leave other types of cells unharmed.

For this reason I want to research a treatment that will benefit the population In a way that will not harm the body. What I hope to achieve is a defined conclusion in which I will find out what monoclonal antibody is the most effective in all areas of my research.

I will be taking an objective approach meaning I will use all the negatives as well as the benefits of each monoclonal antibody to achieve a true conclusion of which is the most effective to the population. Therefore I will try to limit bias in my methods in identifying and rejecting studies. Therefore this should make my conclusions more reliable and accurate.

I will use qualitative and quantitative data to accompany my research, and looking at both experimental research and clinical research as this will enable me to obtain large amounts of information from researchers, relative papers and journals and may more. The quantitative data I will obtain will increase the accuracy of my findings.

I am carrying out this research to show the effectiveness of monoclonal antibodies on cancer. To prove that this is an effective treatment to treating cancer and is the least harmful way.

Other research has shown that these monoclonal antibodies have been effective against non Hodgkin's lymphoma and therefore I want to research deeper to see which is the most effective and come to a conclusion which is the best one to use in non Hodgkin's lymphoma.

I will review all the literature to assess the credibility of the research findings and I will do this by looking at samples of the population for example if they have diabetes, to see if they have the same effect on the whole population. I will also analyse the statistical significance of the results of that particular study. I will also state the factors that are most important to determine whether monoclonal antibodies is the most effective way to treat cancer.

In the research that I carry out I will combine the stats on different findings, to give better evidence for a bigger population as the trials that would be carried out would be small.

I will be looking at the relative trials and studies that have been undertaken by the population to achieve an outcome that will inform the population as to which the most effective in terms of eradicating the cancer, if any. The results that I will obtain from different sources means that it will be easier for me to compare and contrast the information presented so I can come to conclusion quickly and effectively therefore this will display a certain amount of consistency in my findings.

7 Annotated Bibliography.

http://www.ingentaconnect.com

www.lymphoma-net.org

immunology; kuby

www.medscape.com

monoclonal antibodies as therapeutic agents for cancer; M Harris

www.cancerresearchuk.org

 

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